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Index > Protein center > PLCZ1(Gene name) > Human
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  • PLCZ1 (Gene name),
  • 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 (Protein name ),  PLCZ1_HUMAN from NCBI database.
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  • Gene name:
    PLCZ1;
    Protein name:
    1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1;
    Alternative:
    Phospholipase C-zeta-1(PLC-zeta-1);Phosphoinositide phospholipase C-zeta-1;Testis-development protein NYD-SP27;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
    Function:
    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
    Subcellular Location:
    Nucleus Cytoplasm perinuclear region Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
    Protein Attributes:
    Sequence length:
    608
    Sequence:
    50:
    MEMRWFLSKI | QDDFRGGKIN | LEKTQRLLEK | LDIRCSYIHV | KQIFKDNDRL | 
    100:
    KQGRITIEEF | RAIYRIITHR | EEIIEIFNTY | SENRKILLAS | NLAQFLTQEQ | 
    150:
    YAAEMSKAIA | FEIIQKYEPI | EEVRKAHQMS | LEGFTRYMDS | RECLLFKNEC | 
    200:
    RKVYQDMTHP | LNDYFISSSH | NTYLVSDQLL | GPSDLWGYVS | ALVKGCRCLE | 
    250:
    IDCWDGAQNE | PVVYHGYTLT | SKLLFKTVIQ | AIHKYAFMTS | DYPVVLSLEN | 
    300:
    HCSTAQQEVM | ADNLQATFGE | SLLSDMLDDF | PDTLPSPEAL | KFKILVKNKK | 
    350:
    IGTLKETHER | KGSDKRGDNQ | DKETGVKKLP | GVMLFKKKKT | RKLKIALALS | 
    400:
    DLVIYTKAEK | FKSFQHSRLY | QQFNENNSIG | ETQARKLSKL | RVHEFIFHTR | 
    450:
    KFITRIYPKA | TRADSSNFNP | QEFWNIGCQM | VALNFQTPGL | PMDLQNGKFL | 
    500:
    DNGGSGYILK | PHFLRESKSY | FNPSNIKEGM | PITLTIRLIS | GIQLPLTHSS | 
    550:
    SNKGDSLVII | EVFGVPNDQM | KQQTRVIKKN | AFSPRWNETF | TFIIHVPELA | 
    600:
    LIRFVVEGQG | LIAGNEFLGQ | YTLPLLCMNK | GYRRIPLFSR | MGESLEPASL | 
    608:
    FVYVWYVR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    MIM:
    String:
    Pfam:
    UniGene:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    E15484b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    U15484b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    P15484Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    P15484Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Cat.:
    P15484Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Monoclonal Antibody for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
    Protein for Human 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1

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    Precision
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    Linearity
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    References
    1. 1.
      "Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes."
      Cox L.J. , Larman M.G. , Saunders C.M. , Hashimoto K. , Swann K. , Lai F.A.
      Reproduction124:611-623(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
      tissue: Testis.
    2. 2.
      "Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C."
      Zhu H. , Zhu J.X. , Lo P.S. , Li J. , Leung K.M. , Rowlands D.K. , Tsang L.L. , Yu M.K. , Jiang J.L. , Lam S.Y. , Chung Y.W. , Zhou Z. , Sha J. , Chang Chan H.
      Lancet362:2059-2065(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;TISSUE SPECIFICITY
      tissue: Testis.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    5. 5.
      "Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes."
      Rogers N.T. , Hobson E. , Pickering S. , Lai F.A. , Braude P. , Swann K.
      Reproduction128:697-702(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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